One of the most fiercely contested matches in African football, Soweto Derby fixtures have been revealed. Kaizer Chiefs, Orlando Pirates, and the remaining derby between Swallows and Amakhosi, are among the three biggest calendar events on the local fixture list and the dates, venue and time, however, are listed below:
| DATE | HOME TEAM | AWAY TEAM | VENUE | TIME |
| Saturday, 11 September 2021 | Orlando Pirates | Swallows FC | Orlando Stadium | 15:00 |
| Saturday, 6 November 2021 | Kaizer Chiefs | Orlando Pirates | FNB Stadium | 15:30 |
| Sunday, 28 November 2021 | Swallows FC | Kaizer Chiefs | Dobsonville Stadium | 15:30 |
| Saturday, 5 March 2022 | Orlando Pirates | Kaizer Chiefs | Orlando Stadium | 15:30 |
| Sunday, 20 March 2022 | Swallows FC | Orlando Pirates | Dobsonville Stadium | 15:30 |
| Saturday, 21 May 2022 | Kaizer Chiefs | Swallows FC | FNB Stadium | 15:00 |
Pirates and Swallows will go head-to-head in the first Soweto Derby of the new campaign on 11 September at Orlando Stadium at 15:00
That game is followed by the much-anticipated clash between Chiefs and Pirates at FNB Stadium on 6 November, before Swallows play host to the Amakhosi in Dobsonville towards the end of the month.
On 5 March, the Buccaneers will welcome Chiefs to Orlando Stadium before the Glamour Boys entertain Swallows in the final league derby of the season on 21 May, where the two sides will be looking to end the campaign.